Dataset Information


Epigenome analysis of human epidermal and dermal samples with aging and sun exposure

ABSTRACT: Genome wide DNA methylation profiling of epidermal and dermal samples obtained from sun-exposed and sun-protected body sites from younger (<35 years old) and older (>60 years old) individuals. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in dermal and epidermal samples. Samples included 10 younger sun protected dermal samples, 10 younger sun exposed dermal samples, 10 older sun protected dermal samples, 10 older sun exposed dermal samples, 9 younger sun protected epidermal samples, 9 younger sun exposed epidermal samples, 10 older sun protected epidermal sample, 10 older sun exposed epidermal samples. Bisulphite converted DNA from the 78 samples were hybridized to the Illumina Infinium 450k Human Methylation Beadchip.

ORGANISM(S): Homo sapiens  

SUBMITTER: Andrew Feinberg   Amy R Vandiver 

PROVIDER: E-GEOD-51954 | ArrayExpress | 2015-03-23



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Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin.

Vandiver Amy R AR   Irizarry Rafael A RA   Hansen Kasper D KD   Garza Luis A LA   Runarsson Arni A   Li Xin X   Chien Anna L AL   Wang Timothy S TS   Leung Sherry G SG   Kang Sewon S   Feinberg Andrew P AP  

Genome biology 20150416

Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, are well established mechanisms for cancer, and also have emerging roles in aging and common disease. Here, we directly ask whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans.We compare epidermis and dermis of both sun-protected and sun-exposed skin derived from younger subjects (under 35 years old) and older subjects (over 6  ...[more]

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