Dataset Information


Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory

ABSTRACT: TNF is a proinflammatory cytokine with established roles in host defense and immune system organogenesis. Here we report a novel physiological function of TNF that extends its effect beyond the host into the developing offspring. A partial/complete maternal TNF-deficit, specifically in hematopoietic cells, resulted in reduced milk levels of chemokines IP-10, MCP-1/-3/-5, and MIP-1β, which in turn, augmented offspring postnatal hippocampal proliferation, leading to improved adult spatial memory. These effects were reproduced by the postpartum administration of a clinically used anti-TNF agent. Chemokines, fed to suckling pups of TNF-deficient mothers, restored both postnatal proliferation and adult spatial memory to normal levels. This work identifies a TNF-dependent “lactrocrine” pathway that programs offspring hippocampal development and memory. The level of ambient TNF is known to be downregulated by physical activity/exercise and adaptive stress; thus, we propose that the maternal TNF-milk chemokine pathway evolved to promote offspring adaptation to post-weaning environmental challenges/competition. Examined transcriptomes of TNF wild type offspring of TNF wild type or heterozygouse mothers

ORGANISM(S): Mus musculus  

SUBMITTER: Miklos Toth  Emma Laird   Marjan Bozinoski   Bing F Liu   Bojana Zupan   Judit Gal   Shifra L Klein   Shifra Liba Klein   Georgia Gleason    

PROVIDER: E-GEOD-52069 | ArrayExpress | 2014-06-03



altmetric image


Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

| PRJNA226614 | ENA
2013-03-11 | E-GEOD-35838 | ArrayExpress
2013-03-11 | E-GEOD-35854 | ArrayExpress
2014-05-02 | E-GEOD-35815 | ArrayExpress
2011-03-09 | GSE20717 | GEO
2014-05-12 | E-GEOD-44433 | ArrayExpress
2014-07-08 | E-GEOD-47847 | ArrayExpress
2014-07-08 | E-GEOD-47846 | ArrayExpress
2014-05-02 | E-GEOD-20717 | ArrayExpress
2012-03-27 | E-GEOD-6134 | ArrayExpress