Transcriptomics,Multiomics

Dataset Information

5

Glucocorticoid Receptor Confers Resistance to Anti-Androgens by Bypassing Androgen Receptor Blockade.


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Vivek Kumar Arora  

PROVIDER: E-GEOD-52169 | ArrayExpress | 2013-12-27

SECONDARY ACCESSION(S): GSE52169PRJNA227082

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-52169.idf.txt Idf
E-GEOD-52169.processed.1.zip Processed
E-GEOD-52169.sdrf.txt Txt
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Publications


The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR substituted for the androgen receptor (AR) to activate a similar but distinguishable set of target genes and was necessary for maintenance of the resistant phenotype. The GR agonist  ...[more]

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