Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA227163
ORGANISM(S): Mus Musculus
SUBMITTER: Steven H Kleinstein Hailong Meng Loren D Walensky Samuel G Katz
PROVIDER: E-GEOD-52214 | ArrayExpress | 2014-02-05
SECONDARY ACCESSION(S): GSE52214PRJNA227163
REPOSITORIES: GEO, ArrayExpress
Action | DRS | |||
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E-GEOD-52214.additional.1.zip | Other | |||
E-GEOD-52214.idf.txt | Idf | |||
E-GEOD-52214.processed.1.zip | Processed | |||
E-GEOD-52214.sdrf.txt | Txt |
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Katz Samuel G SG Labelle James L JL Meng Hailong H Valeriano Regina P RP Fisher Jill K JK Sun Heather H Rodig Scott J SJ Kleinstein Steven H SH Walensky Loren D LD
Blood 20131218 6
Mantle cell lymphoma (MCL) is a highly aggressive B-cell lymphoma resistant to conventional chemotherapy. Although defined by the characteristic t(11;14) translocation, MCL has not been recapitulated in transgenic mouse models of cyclin D1 overexpression alone. Indeed, several genetic aberrations have been identified in MCL that may contribute to its pathogenesis and chemoresistance. Of particular interest is the frequent biallelic deletion of the proapoptotic BCL-2 family protein BIM. BIM exert ...[more]