Transcriptomics,Multiomics

Dataset Information

3

Cyclin D1 Transgenic Mice with Bim-deficient B-cells


ABSTRACT: Expression analysis from a genetically engineered mouse model of mantle cell lymphoma (MCL) Gene expression was measured in fourteen mice that overexpress cyclin D1 and delete Bim in their B cells and that were stimulated with sheep red blood cells (SRBC) and irradiation (I), pristane (P) or only SRBC weekly (A). Mice that developed disease based on histopathologic criteria were compared to ones that did not. An additional seven stimulated mice that only overexpressed cyclin D1 were used to estimate the data set variance.

OTHER RELATED OMICS DATASETS IN: PRJNA227163

ORGANISM(S): Mus Musculus

SUBMITTER: Steven H Kleinstein   Hailong Meng  Loren D Walensky  Samuel G Katz 

PROVIDER: E-GEOD-52214 | ArrayExpress | 2014-02-05

SECONDARY ACCESSION(S): GSE52214PRJNA227163

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-52214.additional.1.zip Other
E-GEOD-52214.idf.txt Idf
E-GEOD-52214.processed.1.zip Processed
E-GEOD-52214.sdrf.txt Txt
Items per page:
1 - 4 of 4
altmetric image

Publications


Mantle cell lymphoma (MCL) is a highly aggressive B-cell lymphoma resistant to conventional chemotherapy. Although defined by the characteristic t(11;14) translocation, MCL has not been recapitulated in transgenic mouse models of cyclin D1 overexpression alone. Indeed, several genetic aberrations have been identified in MCL that may contribute to its pathogenesis and chemoresistance. Of particular interest is the frequent biallelic deletion of the proapoptotic BCL-2 family protein BIM. BIM exert  ...[more]

Similar Datasets

| E-GEOD-52214 | BioStudies
| S-EPMC3438286 | BioStudies
| S-ECPF-GEOD-48989 | BioStudies
| E-GEOD-48989 | BioStudies
| E-GEOD-43216 | BioStudies
2016-01-01 | S-EPMC4745139 | BioStudies
| S-EPMC2638083 | BioStudies
| S-EPMC4344886 | BioStudies
2013-07-18 | E-GEOD-48989 | ArrayExpress
| S-EPMC7546415 | BioStudies