Dataset Information


Telomerase inhibitor TMPyP4 induced gene expression

ABSTRACT: The effect of TMPyP4, the well established anticancer telomerase inhibitor on genome wide expression of genes was investigated Keywords: Time course Cells were treated with TMPyP4 for either 24 or 48 hours before RNA isolation.Untreated cells were taken as controls and the TMPyP4 treated cells as treatments. Experiments at each time point were replicated four times.

ORGANISM(S): Homo sapiens  

SUBMITTER: Abhay Sharma   Anjali Verma   Shantanu Chowdhury  Farhan Mohd. 

PROVIDER: E-GEOD-5226 | ArrayExpress | 2010-06-10



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Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species.

Verma Anjali A   Halder Kangkan K   Halder Rashi R   Yadav Vinod Kumar VK   Rawal Pooja P   Thakur Ram Krishna RK   Mohd Farhan F   Sharma Abhay A   Chowdhury Shantanu S  

Journal of medicinal chemistry 20080901 18

Using a combination of in silico and experimental approaches, we present evidence that the G-quadruplex (G4) motif (an alternative higher-order DNA conformation) has regulatory potential. Genome-wide analyses of 99980 human, chimpanzee, mouse, and rat promoters showed enrichment of sequence with potential to adopt G4 (potential G4 or PG4) motifs near transcription start sites (TSS; P < 0.0001), supporting earlier findings. Interestingly, we found >700 orthologously related promoters in human, mo  ...[more]

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