Transcriptomics

Dataset Information

9

Microarray analysis of gene expression profiles in PBHA-treated THP-1 cells after LPS stimulation


ABSTRACT: Using microarray analysis, 219 differentially expressed genes were isolated between the LPS group and LPS/PBHA treatment-group (fold change > or < 1.5). These genes were analyzed by KEGG system to reveal the important issues. The analyses of gene ontology were shown that the genes of the specific classes “Chemokine signaling pathway”, ”Cytokine-cytokine receptor interaction”, ”RIG-I-like receptor signaling pathway”, ”Leukocyte transendothelial migration”, and “MAPK signaling pathway” showed markedly different patterns between both groups by KEGG analysis system. In this study presented here, human THP-1 cells were pretreated with only vehicle (resting group), vehicle and LPS (50 ng/ml), or PBHA (10 μM) and LPS (50 ng/ml). After stimulation, the total cellular RNAs were manipulated for analyses of gene expression.

ORGANISM(S): Homo sapiens  

SUBMITTER: Wan-Ru Chang   George Hsiao 

PROVIDER: E-GEOD-52365 | ArrayExpress | 2014-11-17

SECONDARY ACCESSION(S): GSE52365PRJNA227501

REPOSITORIES: GEO, ArrayExpress

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