Dataset Information


Switch Enhancer Elements Control Cell Fate in Human Embryonic Stem Cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Tobias Andreas Beyer  

PROVIDER: E-GEOD-52440 | ArrayExpress | 2013-12-18



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Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

Beyer Tobias A TA   Weiss Alexander A   Khomchuk Yuliya Y   Huang Kui K   Ogunjimi Abiodun A AA   Varelas Xaralabos X   Wrana Jeffrey L JL  

Cell reports 20131212 6

A small toolkit of morphogens is used repeatedly to direct development, raising the question of how context dictates interpretation of the same cue. One example is the transforming growth factor β (TGF-β) pathway that in human embryonic stem cells fulfills two opposite functions: pluripotency maintenance and mesendoderm (ME) specification. Using proteomics coupled to analysis of genome occupancy, we uncover a regulatory complex composed of transcriptional effectors of the Hippo pathway (TAZ/YAP/  ...[more]

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