Transcriptomics

Dataset Information

100

RNA-seq of the brain of Nothobranchius furzeri at different time points


ABSTRACT: Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group

ORGANISM(S): Nothobranchius furzeri  

SUBMITTER: Roberto Ripa  Matthias Platzer   Mario Baumgart   Reinhard Guthke   Eva T Tozzini   Steffen Priebe   Aurora Savino   Marco Groth   Alessandro Cellerino   Giovanna Testa   Michela Ori   Andreas Dix    

PROVIDER: E-GEOD-52462 | ArrayExpress| 2014-09-06

SECONDARY ACCESSION(S): GSE52462SRP033093PRJNA229052

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis.

Baumgart Mario M   Groth Marco M   Priebe Steffen S   Savino Aurora A   Testa Giovanna G   Dix Andreas A   Ripa Roberto R   Spallotta Francesco F   Gaetano Carlo C   Ori Michela M   Terzibasi Tozzini Eva E   Guthke Reinhard R   Platzer Matthias M   Cellerino Alessandro A  

Aging cell 20140725 6


The brains of teleost fish show extensive adult neurogenesis and neuronal regeneration. The patterns of gene regulation during fish brain aging are unknown. The short-lived teleost fish Nothobranchius furzeri shows markers of brain aging including reduced learning performances, gliosis, and reduced adult neurogenesis. We used RNA-seq to quantify genome-wide transcript regulation and sampled five different time points to characterize whole-genome transcript regulation during brain aging of N. fur  ...[more]

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