Transcriptomics

Dataset Information

8

Gene expression profiling regulated by PDGF in pBSMCs


ABSTRACT: To explore global molecular changes in smooth muscle in response to PDGFR activation, primary human bladder smooth muscle cells were treated with 1 nM PDGF-BB (hereafter PDGF) for 0, 4 or 24 h. Total RNA were prepared, and analyzed using expression profiling, and subjected to bioinformatic and functional interrogation. To identify molecular signatures of bladder smooth muscle peturbed by PDGF, primary human bladder smooth muscle cells were treated with 1 nM PDGF-BB (hereafter PDGF) for 0, 4 or 24 h.

ORGANISM(S): Homo sapiens  

SUBMITTER: Sungyong You   Rosalyn M Adam 

PROVIDER: E-GEOD-52488 | ArrayExpress | 2014-10-06

SECONDARY ACCESSION(S): GSE52488PRJNA229097

REPOSITORIES: GEO, ArrayExpress

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Publications

Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells.

Yang Wei W   Ramachandran Aruna A   You Sungyong S   Jeong HyoBin H   Morley Samantha S   Mulone Michelle D MD   Logvinenko Tanya T   Kim Jayoung J   Hwang Daehee D   Freeman Michael R MR   Adam Rosalyn M RM  

Cell communication and signaling : CCS 20140801


Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the proliferation, migration and synthetic activities of smooth muscle cells that characterize physiologic and pathologic tissue remodeling in hollow organs. However, neither the molecular basis of PDGFR-regulated signaling webs, nor the extent to which specific components within these networks could be exploited for therapeutic benefit has been fully elucidated.Expression profiling and quantitative proteomics analysis of PDGF-tr  ...[more]

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