Dataset Information


Large-scale characterization of DNA binding landscape of eukaryotic C2H2 zinc fingers

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative human transcription factors (TFs). However, it is unknown whether most C2H2-ZFs even bind DNA, or what sequences they bind. Using a combination of bacterial one-hybrid (B1H) assays, protein-binding microarrays (PBMs), and ChIP-seq, we have found that most natural C2H2-ZFs bind DNA both in vitro and in vivo. This SuperSeries contains the data for identification of C2H2-ZF binding preferences using these three approaches. Refer to individual Series

ORGANISM(S): synthetic construct  

SUBMITTER: Sanie Mnaimneh  Mihai Albu   Timothy R Hughes   Ernest Radovani   Jack Greenblatt   Hamed S Najafabadi   Ally Yang   Frank W Schmitges    

PROVIDER: E-GEOD-52523 | ArrayExpress | 2015-02-21



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