Transcriptomics

Dataset Information

296

Global analysis of the nuclear processing of unspliced U12-type introns by the exosome


ABSTRACT: we analyzed globally the effect of exosome processing on the nuclear pre-mRNA transcripts by inactivating either the RRP41 or DIS3 subunit of the exosome. Using SOLiD RNA sequencing technology, we report 30-120 million mapped cellular compartment specific reads per sample allowing the detection of unspliced pre-mRNAs. We show that RRP41 and DIS3 knockdowns stabilize an overlapping set of U12-type introns. Studying the global effect of the exosome (Rrp41 or Dis3 subunit) knockdown comparing to the control sample.

ORGANISM(S): Homo sapiens  

SUBMITTER: Elina H Niemelä   Mikko Juhani Frilander  Mikko J Frilander  Dario Greco  Ali Oghabian  Ger Pruijn  Raymond H Staals 

PROVIDER: E-GEOD-52539 | ArrayExpress | 2014-05-26

SECONDARY ACCESSION(S): SRP033138GSE52539PRJNA229174

REPOSITORIES: GEO, ArrayExpress, ENA

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