Transcriptomics

Dataset Information

0

M. tuberculosis Rv3263 Knockout


ABSTRACT: We determine gene expression profile for the knockout of Rv3263 (DNA Methyltransferase) and compared to wildtype M. tuberculosis. Two RNA-Seq datasets are included: wildtype (H37Rv_SS1) and knockout (delta_Rv3263)

ORGANISM(S): Mycobacterium tuberculosis H37Rv  

SUBMITTER: Thomas Ioerger   Thomas R Ioerger  Sarah Fortune  Scarlet Shell 

PROVIDER: E-GEOD-52551 | ArrayExpress | 2013-11-21

SECONDARY ACCESSION(S): GSE52551SRP033148PRJNA229369

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.

Shell Scarlet S SS   Prestwich Erin G EG   Baek Seung-Hun SH   Shah Rupal R RR   Sassetti Christopher M CM   Dedon Peter C PC   Fortune Sarah M SM  

PLoS pathogens 20130704 7


DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase in M. tuberculosis, which we term MamA. MamA creates N⁶-methyladenine in a six base pair recognition sequence present in approximately 2,000 copies on each strand of the genome. Loss of MamA reduces th  ...[more]

Publication: 1/2

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