Transcriptomics

Dataset Information

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Overexpression of UHRF1 drives DNA hypomethylation and hepatocellular carcinoma


ABSTRACT: UHRF1 is an essential regulator of DNA methylation that is highly expressed in many cancers. Using transgenic zebrafish, cultured cells and human tumors, we demonstrate that UHRF1 is an oncogene. RNAseq was used to assess the variation in gene expression between control and experimental samples. Total small RNA from 2 batches of Tg(fabp10:has.UHRF1-GFP)High and age matched Tg(fabp10:nls-mCherry) control 5 dpf zebrafish livers was purified for preparation of high-throughput sequencing libraries.

ORGANISM(S): Danio rerio  

SUBMITTER: Roderick T Bronson   Swan Thung  Augusto Villanueva  Vinitha Jacob  Kensuke Kojima  Ravi Sachidanandam  Josep M Llovet  Raksha Mudbhary  M I Fiel  Kirsten C Sadler  Anja Lachenmayer  Yujin Hoshida  Clara Alsinet  Chinweike Ukomadu  Kate Revill  Xintong Chen  Yelena Chernyavskaya  Anal Desai 

PROVIDER: E-GEOD-52605 | ArrayExpress | 2013-11-22

SECONDARY ACCESSION(S): SRP033231GSE52605PRJNA229468

REPOSITORIES: GEO, ArrayExpress, ENA

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