Transcriptomics

Dataset Information

103

Overexpression of UHRF1 drives DNA hypomethylation and hepatocellular carcinoma


ABSTRACT: UHRF1 is an essential regulator of DNA methylation that is highly expressed in many cancers. Using transgenic zebrafish, cultured cells and human tumors, we demonstrate that UHRF1 is an oncogene. RNAseq was used to assess the variation in gene expression between control and experimental samples. Total small RNA from 2 batches of Tg(fabp10:has.UHRF1-GFP)High and age matched Tg(fabp10:nls-mCherry) control 5 dpf zebrafish livers was purified for preparation of high-throughput sequencing libraries.

ORGANISM(S): Danio rerio  

SUBMITTER: Roderick T Bronson  Swan Thung   Augusto Villanueva   Vinitha Jacob   Kensuke Kojima   Ravi Sachidanandam   Josep M Llovet   Raksha Mudbhary   M I Fiel   Kirsten C Sadler   Anja Lachenmayer   Yujin Hoshida   Clara Alsinet   Chinweike Ukomadu   Kate Revill   Xintong Chen   Yelena Chernyavskaya   Anal Desai    

PROVIDER: E-GEOD-52605 | ArrayExpress | 2014-04-15

SECONDARY ACCESSION(S): SRP033231GSE52605PRJNA229468

REPOSITORIES: GEO, ArrayExpress, ENA

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