Transcriptomics

Dataset Information

3

The effect on lincRNA expression by p53 family members.


ABSTRACT: To evaluate the effect on lincRNA expression by p53 family members, we overexpressed p53 family members in H1299 cells and evaluated the lincRNA expression by microarray analysis. lincRNA expression was measured in H1299 cells infected with adenovirus expressing LacZ, p53, p63a, p63g, p73a and p73b.

ORGANISM(S): Homo sapiens  

SUBMITTER: Masashi Idogawa  

PROVIDER: E-GEOD-52739 | ArrayExpress | 2014-02-05

SECONDARY ACCESSION(S): GSE52739PRJNA229955

REPOSITORIES: GEO, ArrayExpress

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Publications

Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites.

Idogawa Masashi M   Ohashi Tomoko T   Sasaki Yasushi Y   Maruyama Reo R   Kashima Lisa L   Suzuki Hiromu H   Tokino Takashi T  

Human molecular genetics 20140108 11


p53 is one of the most important known tumor suppressor genes, and it is inactivated in approximately half of human cancers. p53 family members execute various functions, such as apoptosis induction and cell cycle arrest, by modulating transcriptional regulation. Therefore, the direct transcriptional targets of the p53 family must be explored to elucidate the functional mechanisms of family members. To identify the direct transcriptional targets of p53 family members, we performed chromatin immu  ...[more]

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