Transcriptomics

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The IclR-family regulator BapR controls biofilms formation in B. cenocepacia H111


ABSTRACT: In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that Quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to BapA, BapR influences the expression of extracellular protease, swimming motility and has a profound impact in the abundance of persister cells, making this regulator an interesting target for persister and biofilm eradication. Identification of a new regulator BapR controlling biofilm formation

ORGANISM(S): Burkholderia cenocepacia H111  

SUBMITTER: Gabriella Pessi   Claudio Aguilar  Martina Lardi  Leo Eberl  Nadine Schmid 

PROVIDER: E-GEOD-52769 | ArrayExpress | 2014-03-26

SECONDARY ACCESSION(S): SRP033349GSE52769PRJNA229987

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

The IclR-family regulator BapR controls biofilm formation in B. cenocepacia H111.

Aguilar Claudio C   Schmid Nadine N   Lardi Martina M   Pessi Gabriella G   Eberl Leo L  

PloS one 20140321 3


In Burkholderia cenocepacia H111, the large surface protein BapA plays a crucial role in the formation of highly structured communities, known as biofilms. We have recently demonstrated that quorum sensing (QS) is necessary for the maximal expression of bapA. In this study we identify BapR, a protein from the IclR family of transcriptional regulators that, in conjunction with QS, controls biofilm formation by affecting the expression of bapA. We present evidence that, in addition to bapA, BapR i  ...[more]

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