Genomics

Dataset Information

346

Epigenome analysis of human epidermal samples with aging and sun exposure


ABSTRACT: Genome wide DNA methylation profiling of epidermal samples obtained from sum-exposed and sun-protected body sites from younger (<35 years old) and older (>60 years old) individuals. Bisulphite converted DNA from 12 samples was sequenced using Illumina HiSeq.

ORGANISM(S): Homo sapiens  

SUBMITTER: Andrew Feinberg   Amy R Vandiver 

PROVIDER: E-GEOD-52972 | ArrayExpress | 2015-03-23

SECONDARY ACCESSION(S): GSE52972SRP033504PRJNA230617

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin.

Vandiver Amy R AR   Irizarry Rafael A RA   Hansen Kasper D KD   Garza Luis A LA   Runarsson Arni A   Li Xin X   Chien Anna L AL   Wang Timothy S TS   Leung Sherry G SG   Kang Sewon S   Feinberg Andrew P AP  

Genome biology 20150416


Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, are well established mechanisms for cancer, and also have emerging roles in aging and common disease. Here, we directly ask whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans.We compare epidermis and dermis of both sun-protected and sun-exposed skin derived from younger subjects (under 35 years old) and older subjects (over 6  ...[more]

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