Transcriptomics

Dataset Information

4

Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.


ABSTRACT: Murine gene expression responses to Bordetella pertussis were determined in lung and spleen, between 0 and 28 days post infection. Data were compared to other parameters such as microarray, flow cytometry, multiplex immunoassays, and lung clearance. A 57 array study with 27 arrays for lung and 30 for spleen. For each tissue we used a common reference made from RNA samples of the same tissue. Please note that the reference samples are made by pooling RNA of all samples used for a tissue (either infected or uninfected). Thus, Lung and spleen each have their own reference.

ORGANISM(S): Mus musculus  

SUBMITTER: Jeroen Pennings  

PROVIDER: E-GEOD-53294 | ArrayExpress | 2014-09-02

SECONDARY ACCESSION(S): GSE53294PRJNA231620

REPOSITORIES: GEO, ArrayExpress

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Publications


Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies. Since natural infections induce a longer-lasting immunity than vaccinations, detailed knowledge of the immune responses following natural infection can provide important clues for such improvement. The purpose was to elucidate the kinetics of the protective immune response evolving after experimental Bordetella pertussis (B. pertussis) infection in mice. Data were collected f  ...[more]

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