Transcriptomics

Dataset Information

6

Radiation-induced genes expressed in two murine tumors.


ABSTRACT: Gene expression profiling was used to identify genes that display radiation-induced transcriptional change over tumor histopathology. Keywords: mouse squamous cell carcinoma, fibrosarcoma and mammary carcinoma, gamma-irradiation, carbon ion irradiation, resected sample, transplanted tissues C3H/HeMs male mice were irradiated by gamma-rays (30Gy, 50Gy, 70Gy) or carbon ions (30Gy) as local irradiation in single doses to hind legs where each tumor was transplanted. Animals were sacrificed either before irradiation (pre) or 1 day after irradiation (day 1) for expression analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Kaori Imadome   Kazunori Nojiri  Mayumi Iwakawa  Takashi Imai 

PROVIDER: E-GEOD-5331 | ArrayExpress | 2009-03-20

SECONDARY ACCESSION(S): GSE5331PRJNA96345

REPOSITORIES: GEO, ArrayExpress

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Publications

The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation.

Nojiri Kazunori K   Iwakawa Mayumi M   Ichikawa Yasushi Y   Imadome Kaori K   Sakai Minako M   Nakawatari Miyako M   Ishikawa Ken-Ichi K   Ishikawa Atsuko A   Togo Shinji S   Tsujii Hirohiko H   Shimada Hiroshi H   Imai Takashi T  

Experimental Biology and Medicine 20081107 1


While the pre-treatment status of cancer is generally correlated with outcome, little is known about microenvironmental change caused by anti-cancer treatment and how it may affect outcome. For example, treatment may lead to induction of gene expression that promotes resistance to therapy. In the present study, we attempted to find a gene that was both induced by irradiation and associated with radioresistance in tumors. Using single-color oligo-microarrays, we analyzed the gene expression profi  ...[more]

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