Genomics

Dataset Information

88

ChIP-Seq of Transcriptional Components in Colon carcinoma


ABSTRACT: Discovery of the genome-wide location of proteins using ChIP-Seq has allowed global mapping of the key transcription factors and chromatin regulators that control gene expression programs in various cells. Many DNA-associated processes are targeted for disease therapy. CDK8 is a kinase component of the Mediator co-activator complex and is often over-expressed in colorectal cancer. This study investigates the genome-wide localization of CDK8 in human colorectal cancer cells. Genomic DNA was enriched by chromatin immunoprecipitation (ChIP) and analyzed by Solexa sequencing. ChIP was performed using an antibody against H3K27ac and CDK8 as well as whole-cell extract (WCE) DNA controls.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jessica Reddy  Richard A Young    

PROVIDER: E-GEOD-53602 | ArrayExpress| 2014-04-15

SECONDARY ACCESSION(S): SRP034697GSE53602PRJNA232472

REPOSITORIES: GEO, ArrayExpress, ENA

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