Genomics

Dataset Information

304

MNase-seq Experiments from Saccharomyces cerevisiae


ABSTRACT: MNase-seq Experiments from Calorie Restricted and Non-Restricted Yeast from WT, ISW2DEL and ISW2K215R strains We used MNase-seq to study genome-wide nucleosome positions under Calorie Restricted and Non-restricted Saccharomyces cerevisiae

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Weiwei Dang   Gabriel L Otte  Shelley L Berger  Jean A Dorsey 

PROVIDER: E-GEOD-53718 | ArrayExpress | 2014-09-15

SECONDARY ACCESSION(S): SRP034842GSE53718PRJNA232719

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications


ATP-dependent chromatin remodeling is involved in all DNA transactions and is linked to numerous human diseases. We explored functions of chromatin remodelers during cellular aging. Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. This extension by ISW2 deletion is epistatic to the longevity effect of calorie restriction (CR), and this mechanism is distinct from suppression of TOR signaling by CR. Transcriptome analysis indicates that isw2Δ  ...[more]

Similar Datasets

2015-09-23 | E-GEOD-65889 | ArrayExpress
2015-11-05 | E-GEOD-73337 | ArrayExpress
2014-10-29 | E-GEOD-52614 | ArrayExpress
2016-03-12 | E-GEOD-72570 | ArrayExpress
2014-09-15 | E-GEOD-53720 | ArrayExpress
| PRJNA90233 | ENA
| PRJNA90237 | ENA
2013-08-01 | E-GEOD-46805 | ArrayExpress
2015-04-02 | E-GEOD-66907 | ArrayExpress
2013-08-01 | E-GEOD-46817 | ArrayExpress