Transcriptomics

Dataset Information

302

RNA-seq Experiments from Saccharomyces cerevisiae


ABSTRACT: RNA-seq Experiments from Calorie Restricted and Non-Restricted WT Yeast We used RNA-seq to study transcriptome changes under Calorie Restricted and Non-restricted Saccharomyces cerevisiae

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Weiwei Dang   Kajia Cao  Shelley L Berger  Jean A Dorsey 

PROVIDER: E-GEOD-53720 | ArrayExpress | 2014-09-15

SECONDARY ACCESSION(S): GSE53720SRP034844PRJNA232717

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


ATP-dependent chromatin remodeling is involved in all DNA transactions and is linked to numerous human diseases. We explored functions of chromatin remodelers during cellular aging. Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. This extension by ISW2 deletion is epistatic to the longevity effect of calorie restriction (CR), and this mechanism is distinct from suppression of TOR signaling by CR. Transcriptome analysis indicates that isw2Δ  ...[more]

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