Dataset Information


An Epigenetic Signature in Peripheral Blood Associated with Neurodegenerative Tauopathy and the Risk-Associated Haplotype on 17q21.31

ABSTRACT: Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) are two neurodegenerative diseases linked, at the pathologic and genetic level, to the macrutubule associated protein tau. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation levels within the region in independent datasets in blood and brain. These data reveal that the H1 haplotype increases risk for tauopathy via differential methylation, indicating a mediating role for methylation in dementia pathophysiology. We studied epigenetic changes (DNA methylation levels) in peripheral blood from patients with PSP, FTD, and unaffected controls. Analysis of genome-wide methylation patterns revealed significant differentially methylated probes in patients versus unaffected controls.

ORGANISM(S): Homo sapiens  

SUBMITTER: Steve Horvath   Anna Karydas  Fuying Gao  Bruce L Miller  Yun Li  Adam L Boxer  Daniel H Geschwind  Howard J Rosen  Giovanni Coppola  Matteo Pellegrini  Renee L Sears  Jason A Chen  Michael D Geschwind  Weilong Guo  Eric D Klein 

PROVIDER: E-GEOD-53740 | ArrayExpress | 2014-06-01



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