Transcriptomics

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3

Involvement of viral miRNA in the regulation of antiviral apoptosis in shrimp


ABSTRACT: In this study, the viral miRNAs from white spot syndrome virus (WSSV) were characterized in shrimp in vivo. On the basis of our previous study and small RNA sequencing in this study, a total of 89 putative WSSV miRNAs were identified. As revealed by miRNA microarray analysis, the expressions of viral miRNAs were tissue-specific in vivo. In this study, the viral miRNAs from white spot syndrome virus (WSSV) were characterized in shrimp in vivo. On the basis of our previous study and small RNA sequencing in this study, a total of 89 putative WSSV miRNAs were identified. As revealed by miRNA microarray analysis and Northern blots, the expressions of viral miRNAs were tissue-specific in vivo. Therefore, our study presented the first report on the in vivo molecular events of viral miRNA in the antiviral apoptosis.

ORGANISM(S): Penaeus japonicus  

SUBMITTER: Yalei Cui   Tianzhi Huang  Xiaobo Zhang 

PROVIDER: E-GEOD-53900 | ArrayExpress | 2014-01-09

SECONDARY ACCESSION(S): GSE53900PRJNA233663

REPOSITORIES: GEO, ArrayExpress

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Involvement of viral microRNA in the regulation of antiviral apoptosis in shrimp.

Huang Tianzhi T   Cui Yalei Y   Zhang Xiaobo X  

Journal of virology 20131218 5


Viruses, in particular DNA viruses, generate microRNAs (miRNAs) to control the expression of host and viral genes. Due to their essential roles in virus-host interactions, viral miRNAs have attracted extensive investigations in recent years. To date, however, most studies on viral miRNAs have been conducted in cell lines. In this study, the viral miRNAs from white spot syndrome virus (WSSV) were characterized in shrimp in vivo. On the basis of our previous study and small RNA sequencing in this  ...[more]

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