Transcriptomics

Dataset Information

34

Expression data of lungs from chickens infected with different H5N1 Avian Influenza Viruses


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Gallus gallus  

SUBMITTER: Jiao Hu   

PROVIDER: E-GEOD-53932 | ArrayExpress| 2015-03-06

SECONDARY ACCESSION(S): GSE53932PRJNA233993

REPOSITORIES: GEO, ArrayExpress

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Publications

PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response.

Hu Jiao J   Mo Yiqun Y   Wang Xiaoquan X   Gu Min M   Hu Zenglei Z   Zhong Lei L   Wu Qiwen Q   Hao Xiaoli X   Hu Shunlin S   Liu Wenbo W   Liu Huimou H   Liu Xiaowen X   Liu Xiufan X  

Journal of virology 20150128 8


PA-X is a newly discovered protein that decreases the virulence of the 1918 H1N1 virus in a mouse model. However, the role of PA-X in the pathogenesis of highly pathogenic avian influenza viruses (HPAIV) of the H5N1 subtype in avian species is totally unknown. By generating two PA-X-deficient viruses and evaluating their virulence in different animal models, we show here that PA-X diminishes the virulence of the HPAIV H5N1 strain A/Chicken/Jiangsu/k0402/2010 (CK10) in mice, chickens, and ducks.  ...[more]

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