Transcriptomics

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Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming


ABSTRACT: We generated induced human hepatocyte by transduction of several lineage specific transcription factors and analyzed the gene expression profile of generated hepatocytes and freshly isolated human hepatocytes through RNA sequencing. Global gene expression profile analysis

ORGANISM(S): Homo sapiens  

SUBMITTER: Jinlin Wang   Jun Jia  Chengang Xiang  Yuanyuan Du  Nan Song 

PROVIDER: E-GEOD-54066 | ArrayExpress | 2014-03-10

SECONDARY ACCESSION(S): SRP035387GSE54066PRJNA234510

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Obtaining fully functional cell types is a major challenge for drug discovery and regenerative medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we show that functional human induced hepatocytes (hiHeps) can be generated from fibroblasts by overexpressing the hepatic fate conversion factors HNF1A, HNF4A, and HNF6 along with the maturation factors ATF5, PROX1, and CEBPA. hiHeps express a spectrum of phase I and II drug-metabolizing enzymes and phase III drug  ...[more]

Publication: 1/2

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