Transcriptomics

Dataset Information

3

Aberrant DNA methylation reprogramming during iPS cell generation is dependent on the choice of reprogramming factors


ABSTRACT: we generate iPSCs from a common fibroblast cell source using either the Yamanaka factors (OCT4, SOX2, KLF4 and MYC) or the Thomson factors (OCT4, SOX2, NANOG and LIN28) and determined their genome-wide DNA methylation profiles. In addition to shared DNA methylation aberrations present in all our iPSCs, we identify Yamanaka-iPSC (Y-iPSCs)-specific and Thomson-iPSCs (T-iPSC)-specific recurrent aberrations. Bisulphite converted DNA from 9 iPS cells derived using Yamanaka factors (OSKM), 6 iPS cells derived using Thompson factors (OSLN), 2 parental fibroblasts and one embrionic ES cell were hybridised to the Illumina Infinium 450k Human Methylation Beadchip

ORGANISM(S): Homo sapiens  

SUBMITTER: D D De Carvalho   N N Batada  Daniel De Carvalho 

PROVIDER: E-GEOD-54115 | ArrayExpress | 2014-01-16

SECONDARY ACCESSION(S): GSE54115PRJNA235202

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-54115.additional.1.zip Other
E-GEOD-54115.idf.txt Idf
E-GEOD-54115.processed.1.zip Processed
E-GEOD-54115.sdrf.txt Txt
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