Genomics

Dataset Information

297

Pregnancy-associated alterations in DNA methylation patterns of mammary epithelial stem cells [mRRBS]


ABSTRACT: Mammary gland development and luminal differentiation occur largely postnatally during puberty and pregnancy. We found that pregnancy had the most significant effects on stem cells, inducing a distinct epigenetic state that remained stable through life. Mammary glands were collected from mice at non-pregnant and pregnant stages for DNA extraction and DNA methylation analysis via mRRBS (multiplexed reduced representation bisulfite sequencing).

ORGANISM(S): Mus musculus  

SUBMITTER: Kornelia Polyak   Sung J Huh  Kendell Clement  Alexander Meissner  Patrick Boyle 

PROVIDER: E-GEOD-54149 | ArrayExpress | 2015-01-22

SECONDARY ACCESSION(S): GSE54149SRP035469PRJNA235306

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Postnatal mammary gland development and differentiation occur during puberty and pregnancy. To explore the role of DNA methylation in these processes, we determined the genome-wide DNA methylation and gene expression profiles of CD24(+)CD61(+)CD29(hi), CD24(+)CD61(+)CD29(lo), and CD24(+)CD61(-)CD29(lo) cell populations that were previously associated with distinct biological properties at different ages and reproductive stages. We found that pregnancy had the most significant effects on CD24(+)C  ...[more]

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