Transcriptomics

Dataset Information

36

Expression profile for PA14 lasR rhlR double mutant with H2O2 stress


ABSTRACT: Quorum sensing controls the expression of multiple virulence factors. PA14 genes lasR and rhlR are necessary for quorum sensing via homoserine lactones. A PA14 lasR rhlR deficient mutant exhibits a reduced oxidative stress response. Here we conducted a microarray to determine oxidative stress response gene regulation mediated by the homoserine lactone quorum sensing circuits. A PA14 lasR rhlR deficient mutant was compared to the wild-type with and without H2O2 stress.

ORGANISM(S): Pseudomonas aeruginosa  

SUBMITTER: García-Contreras Rodolfo  Thomas K. Wood   Wood K Thomas   Belmont A Javier   Jasso-Chávez Ricardo   Maeda Toshinari   Kwan W Brian   Nuñez-López Leslie   Rangel-Vega Adrian    

PROVIDER: E-GEOD-54245 | ArrayExpress | 2015-01-17

SECONDARY ACCESSION(S): GSE54245PRJNA236030

REPOSITORIES: GEO, ArrayExpress

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Publications

Quorum sensing enhancement of the stress response promotes resistance to quorum quenching and prevents social cheating.

García-Contreras Rodolfo R   Nuñez-López Leslie L   Jasso-Chávez Ricardo R   Kwan Brian W BW   Belmont Javier A JA   Rangel-Vega Adrián A   Maeda Toshinari T   Wood Thomas K TK  

The ISME journal 20140617 1


Quorum sensing (QS) coordinates the expression of virulence factors and allows bacteria to counteract the immune response, partly by increasing their tolerance to the oxidative stress generated by immune cells. Despite the recognized role of QS in enhancing the oxidative stress response, the consequences of this relationship for the bacterial ecology remain unexplored. Here we demonstrate that QS increases resistance also to osmotic, thermal and heavy metal stress. Furthermore a QS-deficient las  ...[more]

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