Dataset Information


Systematic Transcriptome Analysis of Zebrafish Model of Diamond-Blackfan Anemia from RPS24 Deficiency

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Danio rerio  

SUBMITTER: yadong yang  

PROVIDER: E-GEOD-54270 | ArrayExpress | 2015-05-18



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Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency.

Song Binfeng B   Zhang Qian Q   Zhang Zhaojun Z   Wan Yang Y   Jia Qiong Q   Wang Xiaomin X   Zhu Xiaofan X   Leung Anskar Yu-Hung AY   Cheng Tao T   Fang Xiangdong X   Yuan Weiping W   Jia Haibo H  

BMC genomics 20140904

BACKGROUND: Diamond-Blackfan anemia (DBA) is a class of human diseases linked to defective ribosome biogenesis that results in clinical phenotypes. Genetic mutations in ribosome protein (RP) genes lead to DBA phenotypes, including hematopoietic defects and physical deformities. However, little is known about the global regulatory network as well as key miRNAs and gene pathways in the zebrafish model of DBA. RESULTS: In this study, we establish the DBA model in zebrafish using an RPS24 morpholino  ...[more]

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