Transcriptomics

Dataset Information

418

High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Musculus  

SUBMITTER: Mumbach Maxwell   Eric S Lander  Aviv Regev  Schraga Schwartz 

PROVIDER: E-GEOD-54365 | ArrayExpress | 2014-07-18

SECONDARY ACCESSION(S): GSE54365PRJNA240098

REPOSITORIES: GEO, ArrayExpress

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Publications


N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins interacting with METTL3, a component of the methyltransferase complex, and show that three of them (WTAP, METTL14, and KIAA1429) are required for methylation. Monitoring m6A levels upon WTAP depletion allowed the definition of accurate and near single-nucleotide resolution methylation maps and their classification into WTAP-dependent and  ...[more]

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