Transcriptomics,Genomics

Dataset Information

98

SOX9: a Stem Cell Transcriptional Regulator of Secreted Niche Signaling Factors


ABSTRACT: Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used RNA-seq to identify SOX9-dependent transcriptional changes and ChIP-seq to identify SOX9-bound genes in HF-SCs. Telogen quiescent hair follicle stem cells (HFSCs) and intefollicular epidermal cells (IFE) were FACS-purified for ChIP-sequcencing and HFSCs for RNA-Sequencing

ORGANISM(S): Mus musculus  

SUBMITTER: Elaine Fuchs  mingyan lin   Meelis Kadaja    

PROVIDER: E-GEOD-54424 | ArrayExpress| 2014-04-15

SECONDARY ACCESSION(S): GSE54424SRP035885PRJNA236480

REPOSITORIES: GEO, ArrayExpress, ENA

altmetric image

Publications

SOX9: a stem cell transcriptional regulator of secreted niche signaling factors.

Kadaja Meelis M   Keyes Brice E BE   Lin Mingyan M   Pasolli H Amalia HA   Genander Maria M   Polak Lisa L   Stokes Nicole N   Zheng Deyou D   Fuchs Elaine E  

Genes & development 20140201 4


Hair follicles (HFs) undergo cyclical periods of growth, which are fueled by stem cells (SCs) at the base of the resting follicle. HF-SC formation occurs during HF development and requires transcription factor SOX9. Whether and how SOX9 functions in HF-SC maintenance remain unknown. By conditionally targeting Sox9 in adult HF-SCs, we show that SOX9 is essential for maintaining them. SOX9-deficient HF-SCs still transition from quiescence to proliferation and launch the subsequent hair cycle. Howe  ...[more]

Similar Datasets

2014-04-15 | E-GEOD-52328 | ArrayExpress
2013-08-22 | E-GEOD-31239 | ArrayExpress
| GSE48878 | GEO
2016-04-15 | E-GEOD-78749 | ArrayExpress
| GSE61316 | GEO
2016-02-21 | E-GEOD-77256 | ArrayExpress
| GSE78749 | GEO
| GSE72863 | GEO
2013-11-25 | E-GEOD-51765 | ArrayExpress
2016-03-06 | E-GEOD-73372 | ArrayExpress