Dataset Information


SOX9: a Stem Cell Transcriptional Regulator of Secreted Niche Signaling Factors

ABSTRACT: Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used RNA-seq to identify SOX9-dependent transcriptional changes and ChIP-seq to identify SOX9-bound genes in HF-SCs. Telogen quiescent hair follicle stem cells (HFSCs) and intefollicular epidermal cells (IFE) were FACS-purified for ChIP-sequcencing and HFSCs for RNA-Sequencing

ORGANISM(S): Mus musculus  

SUBMITTER: Elaine Fuchs   mingyan lin  Meelis Kadaja 

PROVIDER: E-GEOD-54424 | ArrayExpress | 2014-01-28



altmetric image


SOX9: a stem cell transcriptional regulator of secreted niche signaling factors.

Kadaja Meelis M   Keyes Brice E BE   Lin Mingyan M   Pasolli H Amalia HA   Genander Maria M   Polak Lisa L   Stokes Nicole N   Zheng Deyou D   Fuchs Elaine E  

Genes & development 20140201 4

Hair follicles (HFs) undergo cyclical periods of growth, which are fueled by stem cells (SCs) at the base of the resting follicle. HF-SC formation occurs during HF development and requires transcription factor SOX9. Whether and how SOX9 functions in HF-SC maintenance remain unknown. By conditionally targeting Sox9 in adult HF-SCs, we show that SOX9 is essential for maintaining them. SOX9-deficient HF-SCs still transition from quiescence to proliferation and launch the subsequent hair cycle. Howe  ...[more]

Similar Datasets

2013-11-14 | E-GEOD-52328 | ArrayExpress
2011-09-02 | E-GEOD-31239 | ArrayExpress
| GSE48878 | GEO
2016-04-13 | E-GEOD-78749 | ArrayExpress
| GSE61316 | GEO
2016-02-16 | E-GEOD-77256 | ArrayExpress
| GSE78749 | GEO
| GSE72863 | GEO
2013-10-28 | E-GEOD-51765 | ArrayExpress
2016-02-29 | E-GEOD-73372 | ArrayExpress