Dataset Information


Different molecular pathways along with pathogenesis of three subtypes of Leiomyosarcoma

ABSTRACT: Leiomyosarcoma (LMS) is a malignant neoplasm of smooth muscle and is an aggressive soft tissue tumor, have complex genetic abnormalities and could be defined as three molecular subtypes. Since that the molecular heterogeneity of LMS, the pathogenesis analysis per subtype will be highly necessary and helpful to understand the etiology of this more common sarcoma. Within this study, we collected four Myometrium, three Leiomyoma, three LMS cell lines and 99 LMSs (GSE45510), performed the system-wide gene expression profiling by 3'end RNA Sequencing, and found that there are significant different molecular pathways along the pathogenesis for those three molecular subtypes.

ORGANISM(S): Homo sapiens  

SUBMITTER: Robert B West   Matt van de Rijn  Xiangqian Guo  Shirley X Zhu  Sushama Varma 

PROVIDER: E-GEOD-54511 | ArrayExpress | 2015-05-19



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Clinically Relevant Molecular Subtypes in Leiomyosarcoma.

Guo Xiangqian X   Jo Vickie Y VY   Mills Anne M AM   Zhu Shirley X SX   Lee Cheng-Han CH   Espinosa Inigo I   Nucci Marisa R MR   Varma Sushama S   Forgó Erna E   Hastie Trevor T   Anderson Sharon S   Ganjoo Kristen K   Beck Andrew H AH   West Robert B RB   Fletcher Christopher D CD   van de Rijn Matt M  

Clinical cancer research : an official journal of the American Association for Cancer Research 20150420 15

Leiomyosarcoma is a malignant neoplasm with smooth muscle differentiation. Little is known about its molecular heterogeneity and no targeted therapy currently exists for leiomyosarcoma. Recognition of different molecular subtypes is necessary to evaluate novel therapeutic options. In a previous study on 51 leiomyosarcomas, we identified three molecular subtypes in leiomyosarcoma. The current study was performed to determine whether the existence of these subtypes could be confirmed in independen  ...[more]

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