Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA237221
ORGANISM(S): Homo sapiens
SUBMITTER: Antonio Cappuccio Takeshi Satoh Maximilien Grandclaudon Carolina Martinez-Cingolani Vassili Soumelis Nicolas Servant Nicolas Manel Maxime Touzot
PROVIDER: E-GEOD-54627 | ArrayExpress | 2014-05-29
SECONDARY ACCESSION(S): GSE54627PRJNA237221
REPOSITORIES: GEO, ArrayExpress
Action | DRS | |||
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E-GEOD-54627.idf.txt | Idf | |||
E-GEOD-54627.processed.1.zip | Processed | |||
E-GEOD-54627.raw.1.zip | Raw | |||
E-GEOD-54627.raw.2.zip | Raw | |||
E-GEOD-54627.sdrf.txt | Txt |
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Nature communications 20140528
In an inflammatory microenvironment, multiple cytokines may act on the same target cell, creating the possibility for combinatorial interactions. How these may influence the system-level function of a given cytokine is unknown. Here we show that a single cytokine, interferon (IFN)-alpha, can generate multiple transcriptional signatures, including distinct functional modules of variable flexibility, when acting in four cytokine environments driving distinct T helper cell differentiation programs ...[more]