Transcriptomics

Dataset Information

32

Whole-blood transcriptomic profiling highlights rituximab response in rheumatoid arthritis


ABSTRACT: Objective: We performed whole-blood transcriptomic profiling for patients with rheumatoid arthritis (RA) who received rituximab (RTX). We aimed to identify a molecular signature that could predict the clinical response to RTX and transcriptomic changes after RTX therapy. Methods: We performed a microarray assay of the whole human genome with RNA from a peripheral blood sample taken before the first RTX cycle from 68 patients included in the SMART study (24 EULAR non-responders and 44 responders at week 24). The transcriptomic profile was also assessed 24 weeks after the first RTX administration

ORGANISM(S): Homo sapiens  

SUBMITTER: S Jacques  J Tebib   G Chiocchia   J Sibilia   S Marion-Thore   X L Loët   X Mariette   F Dumont   J Sellam   S Rouanet   Y Taoufik   B Combe   H-J Garchon   Florent Dumont   H Chavez   M Dougados    

PROVIDER: E-GEOD-54629 | ArrayExpress| 2015-01-20

SECONDARY ACCESSION(S): GSE54629PRJNA237237

REPOSITORIES: GEO, ArrayExpress

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