Transcriptomics

Dataset Information

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Fatima Al-Shahrour  

PROVIDER: E-GEOD-54646 | ArrayExpress | 2014-06-03

SECONDARY ACCESSION(S): GSE54646PRJNA237274

REPOSITORIES: GEO, ArrayExpress

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Publications


Genomic studies have identified somatic alterations in the majority of myeloproliferative neoplasms (MPN) patients, including JAK2 mutations in the majority of MPN patients and CALR mutations in JAK2-negative MPN patients. However, the role of JAK-STAT pathway activation in different MPNs, and in patients without JAK2 mutations, has not been definitively delineated. We used expression profiling, single nucleotide polymorphism arrays, and mutational profiling to investigate a well-characterized c  ...[more]

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