Transcriptomics

Dataset Information

120

Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program [array]


ABSTRACT: Previous studies have shown that FOXA1 defines prostatic AR binding events, the underlying mechanisms of which, however, are incompletely understood. To test whether ectopic AR and FOXA1 can activate AR target genes, we performed adenoviral of LacZ, AR, FOXA1 or AR+FOXA1 proteins in DU145 cells, followed by microarray analysis of these cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jindan Yu   Hong-Jian Jin 

PROVIDER: E-GEOD-54991 | ArrayExpress | 2014-06-02

SECONDARY ACCESSION(S): GSE54991PRJNA238217

REPOSITORIES: GEO, ArrayExpress

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Publications

Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program.

Jin Hong-Jian HJ   Zhao Jonathan C JC   Wu Longtao L   Kim Jung J   Yu Jindan J  

Nature communications 20140530


The pioneering factor FOXA1 opens chromatin to facilitate androgen receptor (AR) binding to prostate-specific genes. How FOXA1 controls the AR cistrome, however, is incompletely understood. Here we show that AR directly binds chromatin through the androgen response elements (AREs). FOXA1 is not required for AR-chromatin interaction, but instrumental in recruiting AR to low-affinity half-AREs by opening local chromatin around adjacent FKHD sites. Too much FOXA1 creates excessive open chromatin re  ...[more]

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