Transcriptomics

Dataset Information

2

A-CGH of Esophageal Cancer (53 cases)


ABSTRACT: Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC). Currently, there are limited clinical approaches for early diagnosis and treatment for ESCC, resulting in a 10% 5-year survival rate for the patients. Meanwhile, the full repertoire of genomic events leading to the pathogenesis of ESCC remains unclear. Here we show a comprehensive genomic analysis in 158 ESCC cases, as part of the International Cancer Genome Consortium (ICGC) Research Projects (http://icgc.org/icgc/cgp/72/371/1001734). We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases and additional 70 ESCC cases were subjected to array comparative genomic hybridization (a-CGH) analysis. We conducted whole-genome sequencing in 17 ESCC cases and whole-exome sequencing in 71 cases, of which 53 cases and additional 70 ESCC cases were subjected to array comparative genomic hybridization (a-CGH) analysis.

ORGANISM(S): Homo sapiens  

SUBMITTER: Zhibo Gao   Lin Li  Yunwei Ou  Yongmei Song  Qimin Zhan 

PROVIDER: E-GEOD-54994 | ArrayExpress | 2014-03-11

SECONDARY ACCESSION(S): GSE54994PRJNA238220

REPOSITORIES: GEO, ArrayExpress

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