Genomics

Dataset Information

58

Genome-wide changes in DNase-hypersensitivity during osteoblastogenesis reveal differential usage of DNA motifs and define novel cis-regulatory regions that control gene expression during differentiation


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Jane Lian   

PROVIDER: E-GEOD-55047 | ArrayExpress| 2015-05-23

SECONDARY ACCESSION(S): GSE55047PRJNA238320

REPOSITORIES: GEO, ArrayExpress

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Publications

The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.

Barutcu A Rasim AR   Tai Phillip W L PW   Wu Hai H   Gordon Jonathan A R JA   Whitfield Troy W TW   Dobson Jason R JR   Imbalzano Anthony N AN   Lian Jane B JB   van Wijnen André J AJ   Stein Janet L JL   Stein Gary S GS  

Nucleic acids research 20140812 16


Three-dimensional organization of chromatin is fundamental for transcriptional regulation. Tissue-specific transcriptional programs are orchestrated by transcription factors and epigenetic regulators. The RUNX2 transcription factor is required for differentiation of precursor cells into mature osteoblasts. Although organization and control of the bone-specific Runx2-P1 promoter have been studied extensively, long-range regulation has not been explored. In this study, we investigated higher-order  ...[more]

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