Dataset Information


Effect of NDRG3 overexpression on cell response to hypoxia

ABSTRACT: Analysis of HeLa cells overexpressing NDRG3 or exposed to hypoxic condition. Gene expression profiles of HeLa cells stably expressing NDRG3 were compared to gene expression profiles of HeLa stable cells expressing mock or hypoxia-mediated gene expression profiles.

ORGANISM(S): Homo sapiens  

SUBMITTER: Minho Kang   Young I Yeom  Dong C Lee  Ye J Jang 

PROVIDER: E-GEOD-55211 | ArrayExpress | 2015-07-24



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Organisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, but evidence indicates that other, HIF-independent mechanisms are also involved. Here, we report a hypoxic response that depends on the accumulation of lactate, a metabolite whose production increases in hypoxic conditions. We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normo  ...[more]

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