Dataset Information


Perinatal malnutrition in male mice influences gene expression in the next generation offspring: Potential role of epigenetics.

ABSTRACT: Perinatal nutritional imbalances may have long-lasting consequences on health and disease, increasing risk of obesity, insulin resistance, type 2 diabetes or cardiovascular disease. This idea has been conceptualized in the Developmental Origins of Health and Disease Hypothesis (DOHaD). In addition, there is evidence that such early-programmed phenotypes can be transmitted to the following generation(s). It is proposed that, environmentally induced, transmission of disease risk is mediated by epigenetic mechanisms. The aim of this study was to determine whether patterns of gene expression in the first generation offspring are also present in the following generation offspring, via the paternal lineage. Paternal transmission of patterns of gene expression strongly suggest epigenetic inheritance of disease risk. Liver tissue was obtained from the follwing experimental groups: a) control male mice, b) adult male mice previously exposed to 50% caloric restriction in utero (IUGR), c) adult male mice overfed during lactation (ON), d) adult male offspring from control mice, e) adult male offspring from IUGR mice and f) adult male offspring from ON mice.RNA was extracted and processed for further hybridization on Affymetrix microarrays (GeneChip Mouse Genome 430 2.0 (Affymetrix, Santa Clara, CA)).

ORGANISM(S): Mus musculus  

SUBMITTER: Susana G Kalko   Josep C Jimenez-Chillaron  Susana Kalko 

PROVIDER: E-GEOD-55304 | ArrayExpress | 2015-02-01



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In utero undernutrition in male mice programs liver lipid metabolism in the second-generation offspring involving altered Lxra DNA methylation.

Martínez Débora D   Pentinat Thais T   Ribó Sílvia S   Daviaud Christian C   Bloks Vincent W VW   Cebrià Judith J   Villalmanzo Nuria N   Kalko Susana G SG   Ramón-Krauel Marta M   Díaz Rubén R   Plösch Torsten T   Tost Jörg J   Jiménez-Chillarón Josep C JC  

Cell metabolism 20140501 6

Obesity and type 2 diabetes have a heritable component that is not attributable to genetic factors. Instead, epigenetic mechanisms may play a role. We have developed a mouse model of intrauterine growth restriction (IUGR) by in utero malnutrition. IUGR mice developed obesity and glucose intolerance with aging. Strikingly, offspring of IUGR male mice also developed glucose intolerance. Here, we show that in utero malnutrition of F1 males influenced the expression of lipogenic genes in livers of F  ...[more]

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