Transcriptomics

Dataset Information

6

DNA damage signaling gene array on SMA mouse skeletal muscle


ABSTRACT: A commercially available gene array (SABiosciences array PAMM-029ZD-12) was used to assay gene expression in skeletal muscle of SMA mice and control littermates. The Taiwanese severe SMA mouse model was used (Hsieh-Li et al. 2000). The array included 84 genes associated with DNA damage detection, DNA repair, apoptosis, cell cycle, and other functions. SMA group (n=3) vs. control group (n=3) - single technical replicates, triple biological replicates

ORGANISM(S): Mus musculus  

SUBMITTER: Saniya Fayzullina   Lee J Martin 

PROVIDER: E-GEOD-55481 | ArrayExpress | 2014-03-03

SECONDARY ACCESSION(S): GSE55481PRJNA239719

REPOSITORIES: GEO, ArrayExpress

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Publications

Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA).

Fayzullina Saniya S   Martin Lee J LJ  

PloS one 20140325 3


Spinal Muscular Atrophy (SMA) is a hereditary childhood disease that causes paralysis by progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. The mechanisms by which lack of SMN causes SMA pathology are not known, making it very difficult to develop effective therapies. We investigated whether DNA damage is a perinatal pathologica  ...[more]

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