Transcriptomics

Dataset Information

4

MiRNA expression in fast and slow skeletal muscle of wild type and SOD1-G93A mice


ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively debilitates neuronal cells that control voluntary muscle activity. In a mouse model of ALS that expresses mutated human superoxide dismutase 1 (SOD1-G93A) skeletal muscle is one of the tissues affected early by mutant SOD1 toxicity. Fast-twitch and slow-twitch muscles are differentially affected in ALS patients and in the SOD1-G93A model, fast-twitch muscles being more vulnerable. We used miRNA microarrays to investigate miRNA alterations in fast-twitch (EDL) and slow-twitch (soleus) skeletal muscles of symptomatic SOD1-G93A animals and their age-matched wild type littermates. At age of 90 days RNA was extracted from extensor digitorum longus (EDL) and soleus (SOL) muscles of male SOD1-G93A animals and their age-matched wild type male littermates. RNA was hybridized on Affymetrix Multispecies miRNA-2_0 Array.

ORGANISM(S): Mus musculus  

SUBMITTER: Sara Olivan   Raquel Manzano  Rosario Osta  Alberto Garcia-Redondo  Janne M Toivonen  Pilar Zaragoza 

PROVIDER: E-GEOD-55507 | ArrayExpress | 2014-03-04

SECONDARY ACCESSION(S): GSE55507PRJNA239806

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis.

Toivonen Janne M JM   Manzano Raquel R   Oliván Sara S   Zaragoza Pilar P   García-Redondo Alberto A   Osta Rosario R  

PloS one 20140220 2


Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively debilitates neuronal cells that control voluntary muscle activity. Biomarkers are urgently needed to facilitate ALS diagnosis and prognosis, and as indicators of therapeutic response in clinical trials. microRNAs (miRNAs), small posttranscriptional modifiers of gene expression, are frequently altered in disease conditions. Besides their important regulatory role in variety of biological processes, miRNAs can  ...[more]

Similar Datasets

2019-03-21 | PXD010553 | Pride
| GSE111148 | GEO
2005-10-30 | E-MEXP-453 | ArrayExpress
2009-10-17 | GSE18597 | GEO
2009-10-17 | E-GEOD-18597 | ArrayExpress
2008-06-11 | E-GEOD-10953 | ArrayExpress
2007-12-14 | E-GEOD-4390 | ArrayExpress
2008-03-27 | GSE10953 | GEO
2014-12-17 | E-GEOD-49023 | ArrayExpress
| GSE10454 | GEO