Transcriptomics

Dataset Information

4

Effects of SGI-110 on A2780 ovarian cancer xenografts


ABSTRACT: Genome-wide DNA methylation profiles of SGI-110-treated ovarian cancer xenografts were obtained using next generation Illumina Infinium 450k assay which includes over 450,000 GpG sites. DNA from 6 samples were hybridized to the Illumina's Infinium HumanMethylation 450 BeadChip

ORGANISM(S): Homo sapiens  

SUBMITTER: Matthew W Segar   Daniela Matei  Horacio Cardenas  Yunlong Liu 

PROVIDER: E-GEOD-55613 | ArrayExpress | 2014-10-02

SECONDARY ACCESSION(S): GSE55613PRJNA240219

REPOSITORIES: GEO, ArrayExpress

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Publications


Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer. As epigenetic regulators play a major role in the control of normal stem cell differentiation, epigenetics may offer a useful arena to develop strategies to target cancer stem-like cells. Epigenetic aberrations, especially DNA methylation, silence tumor-suppressor and differentiation-associated genes that regulate the survival of ovarian cancer  ...[more]

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