Transcriptomics,Genomics,Multiomics

Dataset Information

45

ARRB1 regulates prostate cancer cell metabolism


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Silvia Halim   

PROVIDER: E-GEOD-55616 | ArrayExpress | 2014-11-28

SECONDARY ACCESSION(S): GSE55616PRJNA240220

REPOSITORIES: GEO, ArrayExpress

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Publications


Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well documented. Here, using an integrative approach combining the first genome-wide mapping of chromatin binding for an endocytic adaptor, ARRB1  ...[more]

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