Transcriptomics

Dataset Information

238

White Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in Candida albicans


ABSTRACT: Modes of sexual reproduction in eukaryotic organisms are highly diversified. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally and morphologically differentiated white and opaque cells show a coordinating behavior in the process of mating. Although white cells are mating-incompetent, they are induced to produce sexual pheromones when treated with opposite pheromones or interacted with opaque cells of an opposite mating type. In a co-culture system, pheromones released by white cells induce opaque cells to form mating projections and thus facilitate both opposite- and same-sex mating of opaque cells. Deletion of genes encoding the pheromone precursor proteins and inactivation of the pheromone response signaling pathway (Ste2-MAPK-Cph1) impair the promoting role of white cells (MTLa) in sexual mating of opaque cells. White and opaque cells communicate via a paracrine pheromone signaling and thus create an environment conducive to sexual mating. This coordination behavior of the two different cell types may be a trade-off strategy between sexual and asexual lifestyles in C. albicans. total RNA profiles of white cell treated with pheromone

ORGANISM(S): Candida albicans  

SUBMITTER: Chengjun Cao   Guanghua Huang  Li Tao  guanghua huang 

PROVIDER: E-GEOD-56039 | ArrayExpress | 2014-10-23

SECONDARY ACCESSION(S): SRP040313GSE56039PRJNA242279

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.

Tao Li L   Cao Chengjun C   Liang Weihong W   Guan Guobo G   Zhang Qiuyu Q   Nobile Clarissa J CJ   Huang Guanghua G  

PLoS genetics 20141016 10


Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally- and morphologically-differentiated white and opaque cells show a coordinated behavior during mating. Although white cells are mating-incompetent, they can produce sexual pheromones when treated with pheromones of the opposite mating ty  ...[more]

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