Transcriptomics

Dataset Information

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Expression data from EμMyc;Prdm11 WT and EμMyc;Prdm11 KO end-stage splenic tumors


ABSTRACT: The PR-domain family (PRDMs) encodes transcriptional regulators, several of which are deregulated in cancer. We found that loss of Prdm11 accelerates MYC-driven lymphomagenesis in the Eµ-Myc mouse model. Expression data from EμMyc;Prdm11 WT and EμMyc;Prdm11 KO end-stage splenic tumors to identify genes deregulated by loss of Prdm11 9 EμMyc;Prdm11 WT and 9 EμMyc;Prdm11 KO end-stage splenic tumors

OTHER RELATED OMICS DATASETS IN: E-GEOD-56235

ORGANISM(S): Mus musculus  

SUBMITTER: Cathrine K Fog   Anders H Lund 

PROVIDER: E-GEOD-56063 | ArrayExpress | 2015-03-02

SECONDARY ACCESSION(S): GSE56063PRJNA242328

REPOSITORIES: GEO, ArrayExpress

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Publications


The PR-domain (PRDM) family of genes encodes transcriptional regulators, several of which are deregulated in cancer. By using a functional screening approach, we sought to identify novel tumor suppressors among the PRDMs. Here we demonstrate oncogenic collaboration between depletion of the previously uncharacterized PR-domain family member Prdm11 and overexpression of MYC. Overexpression of PRDM11 inhibits proliferation and induces apoptosis. Prdm11 knockout mice are viable, and loss of Prdm11 a  ...[more]

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