Transcriptomics,Genomics

Dataset Information

0

PRDM11: a novel tumor suppressor


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

OTHER RELATED OMICS DATASETS IN: E-GEOD-56235

ORGANISM(S): Musculus  

SUBMITTER: Anders H Lund  

PROVIDER: E-GEOD-56065 | ArrayExpress | 2015-03-02

SECONDARY ACCESSION(S): GSE56065PRJNA242330

REPOSITORIES: GEO, ArrayExpress

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Publications


The PR-domain (PRDM) family of genes encodes transcriptional regulators, several of which are deregulated in cancer. By using a functional screening approach, we sought to identify novel tumor suppressors among the PRDMs. Here we demonstrate oncogenic collaboration between depletion of the previously uncharacterized PR-domain family member Prdm11 and overexpression of MYC. Overexpression of PRDM11 inhibits proliferation and induces apoptosis. Prdm11 knockout mice are viable, and loss of Prdm11 a  ...[more]

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