Dataset Information


Genome-wide analysis of H3K4me1 in Lsh-/- mouse embryonic fibroblasts

ABSTRACT: We report here differentiated enrichment of H3K4me1 at Lsh WT and KO mouse embryonic fibroblasts (MEFs). We found a subset of differentially enriched H3K4me1 regions in Lsh KO MEFs, and they clustered at neuronal lineage genes and overlapping with known cis-regulatory elements present in brain tissue. Reprogramming of Lsh−/− MEFs into induced pluripotent stem (iPS) cells leads to increased neuronal lineage gene expression of premarked genes and enhanced differentiation potential of Lsh−/− iPS cells toward the neuronal lineage pathway compared with WT iPS cells in vitro and in vivo. The state of H3K4me1 enrichment is partially maintained in Lsh−/− iPS cells, suggesting the regions are preserved as potential enhancers. Genome-wide maps of H3K4me1 in Lsh WT and KO primary MEFs.

ORGANISM(S): Mus musculus  

SUBMITTER: Kathrin Muegge   Weishi Yu 

PROVIDER: E-GEOD-56151 | ArrayExpress | 2014-03-25



Similar Datasets

2014-06-24 | E-GEOD-57419 | ArrayExpress
2014-06-13 | E-GEOD-57486 | ArrayExpress
2011-05-19 | E-GEOD-29393 | ArrayExpress
2011-05-19 | E-GEOD-29394 | ArrayExpress
2011-05-19 | E-GEOD-29392 | ArrayExpress
2012-10-01 | E-GEOD-40286 | ArrayExpress
| PRJNA142995 | ENA
2012-06-19 | E-GEOD-23116 | ArrayExpress
2016-07-21 | E-GEOD-64384 | ArrayExpress
| GSE29393 | GEO