Genomics

Dataset Information

299

Genome-wide analysis of H3K4me1 in Lsh-/- mouse embryonic fibroblasts


ABSTRACT: We report here differentiated enrichment of H3K4me1 at Lsh WT and KO mouse embryonic fibroblasts (MEFs). We found a subset of differentially enriched H3K4me1 regions in Lsh KO MEFs, and they clustered at neuronal lineage genes and overlapping with known cis-regulatory elements present in brain tissue. Reprogramming of Lsh−/− MEFs into induced pluripotent stem (iPS) cells leads to increased neuronal lineage gene expression of premarked genes and enhanced differentiation potential of Lsh−/− iPS cells toward the neuronal lineage pathway compared with WT iPS cells in vitro and in vivo. The state of H3K4me1 enrichment is partially maintained in Lsh−/− iPS cells, suggesting the regions are preserved as potential enhancers. Genome-wide maps of H3K4me1 in Lsh WT and KO primary MEFs.

ORGANISM(S): Mus musculus  

SUBMITTER: Kathrin Muegge   Weishi Yu 

PROVIDER: E-GEOD-56151 | ArrayExpress | 2014-03-25

SECONDARY ACCESSION(S): SRP040524GSE56151PRJNA242559

REPOSITORIES: GEO, ArrayExpress, ENA

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