Genomics

Dataset Information

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MethylC-Seq of ago6-2, ago4-6 and ago4-6 ago6-2 double mutants


ABSTRACT: Using MethylC-Seq to provide single-base resolution of DNA methylation status in ago6-2, ago4-6 and ago4-6 ago6-2 double mutants MethylC-Seq: 3 mutants examined, ago6-2, ago4-6 single mutant and ago4-6 ago6-2 double mutants

ORGANISM(S): Arabidopsis thaliana  

SUBMITTER: Jian-Kang Zhu   Huiming Zhang  Cheng-Guo Duan  Kai Tang 

PROVIDER: E-GEOD-56388 | ArrayExpress | 2015-01-06

SECONDARY ACCESSION(S): SRP040746GSE56388PRJNA243092

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Argonaute (AGO) family proteins are conserved key components of small RNA-induced silencing pathways. In the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis, AGO6 is generally considered to be redundant with AGO4. In this report, our comprehensive, genomewide analyses of AGO4- and AGO6-dependent DNA methylation revealed that redundancy is unexpectedly negligible in the genetic interactions between AGO4 and AGO6. Immunofluorescence revealed that AGO4 and AGO6 differ in their subnuclear  ...[more]

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