Transcriptomics

Dataset Information

297

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish


ABSTRACT: ATF6 is a key regulator of the unfolded protein response. Through use of zebrafish and cultured cells we demonstrate that ATF6 drives fatty liver disease by interaction with fatty acid synthase (FASN). Total small RNA from livers of 5 dpf larval zebrafish were collected: 2 batches of Tg(fabp10:nls-mCherry) control larvae, 2 batches of ethanol-treated Tg(fabp10:nls-mCherry) larvae, and 1 batch of Tg(fabp10:nAtf6-cherry; cmlc2:GFP). Each batch was purified for preparation of high-throughput sequencing libraries.

ORGANISM(S): Danio rerio  

SUBMITTER: Orkhontuya Tsedensodnom   Ana M Vacaru  Taisa Vasilkova  Christoph Buettner  Ravi Sachidanandam  Claudia Lindtner  Kirsten C Sadler  Deanna L Howarth 

PROVIDER: E-GEOD-56498 | ArrayExpress | 2014-05-01

SECONDARY ACCESSION(S): GSE56498SRP040940PRJNA243510

REPOSITORIES: GEO, ArrayExpress, ENA

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